James Bagnall

Dr. James Bagnall is a Research Fellow at the University of Manchester's Faculty of Biology, Medicine and Health, specifically within the Division of Neuroscience and Experimental Psychology. His research spans molecular biology, immunology, and chronobiology, focusing on the intersection of circadian rhythms and cellular signaling pathways. With a robust publication record extending to 2025, he maintains an active research program investigating how biological clocks regulate cellular functions in both healthy and disease states.

• ORCID: 0000-0003-1735-5855
• Primary research institution: University of Manchester
• Research focus areas: Circadian biology, macrophage function, NF-κB signaling

Dr. Bagnall's research interests center on understanding how circadian rhythms regulate fundamental cellular processes. His work demonstrates that biological clocks exert precise temporal control over gene expression, protein dynamics, and cellular responses to environmental stimuli. He has made significant contributions to understanding how the circadian system regulates macrophage function, inflammatory responses, and kidney physiology. His approach integrates quantitative live-cell imaging, mathematical modeling, and molecular biology to reveal the mechanisms underlying circadian control of cellular processes.

Analysis of Dr. Bagnall's publication record reveals a clear trajectory of research focused on quantitative approaches to understanding circadian regulation. His work consistently applies advanced imaging techniques to study protein dynamics in living cells, particularly focusing on the suprachiasmatic nucleus (the master circadian clock) and immune cells. A notable theme is how circadian mechanisms interact with inflammatory pathways, particularly the NF-κB signaling system. More recent publications demonstrate expanding applications of his expertise to renal physiology and pulmonary function.

Dr. Bagnall has contributed to research that has been recognized through citations and social media engagement, with several papers receiving attention from news outlets and academic sharing platforms. His dataset on hypoxia-inducible factors was notably picked up by 4 news outlets and shared across multiple social media platforms.

His research methodology emphasizes quantitative approaches to cell signaling, with particular expertise in live-cell imaging of dynamic processes. Dr. Bagnall frequently collaborates with interdisciplinary teams that combine expertise in molecular biology, mathematics, and clinical medicine, reflecting the translational nature of his work on circadian biology and its implications for human health.