Jai Subramanian

Jai Subramanian is an Associate Professor in the Department of Pharmacology & Toxicology at the University of Kansas. His research investigates synaptic plasticity mechanisms in learning and memory, particularly their dysfunction in neurodegenerative disorders like Alzheimer's disease.

• Education: Ph.D. in Molecular Biology from University of Southern California (2004), Postdoctoral Fellow at NIH (2011), Research Scientist at MIT (2017)

Using advanced techniques such as single-neuron genetic manipulations, in vivo synaptic labeling, and multi-color two-photon imaging, his work reveals how amyloid pathology disrupts experience-dependent plasticity and alters excitation-inhibition balance in cortical circuits.

Recent publications highlight amyloid-beta interactions with clusterin oxidation, visual network c-Fos abnormalities, and experience-driven neural activity patterns in transgenic models. His methodologies combine mouse models with longitudinal imaging to track synaptic dynamics.