Jacob Hoogenboom

Jacob Hoogenboom (born 1972) is an Associate Professor at Delft University of Technology in the Department of Imaging Physics within the Faculty of Applied Sciences. He leads the Hoogenboom Lab, which specializes in integrated light and electron microscopy techniques. His research group is part of the DEMI (Delft Electron Microscopy Initiative) and actively participates in NEMI (the Netherlands Electron Microscopy Infrastructure).

Hoogenboom earned his PhD from Utrecht University in September 2002 for research conducted at the FOM Institute for Atomic and Molecular Physics (AMOLF) in Amsterdam. He subsequently worked as a postdoctoral researcher at the MESA+ Institute for Nanotechnology at University of Twente and as a research fellow at ICFO - the Institute of Photonic Sciences in Barcelona, Spain. In 2008, he joined TU Delft as an Associate Professor after spending 8 months at Utrecht University.

His research focuses on developing integrated microscopy techniques that combine the strengths of light and electron microscopy. Key areas include correlative microscopy (particularly SEM fluorescence CLEM), ultrafast microscopy, molecular nanophotonics, and light-electron-matter interactions. His lab aims to overcome limitations of existing microscopes by physically integrating different modalities into single instruments, enabling higher precision, super-resolution imaging, and faster detection.

Analysis of his recent publications (2024-2025) reveals a strong focus on advancing correlative cryo-electron microscopy techniques, particularly workflows for fluorescence-targeted lamella milling from vitrified cells. His work bridges fundamental physics with practical applications in life sciences and materials research, emphasizing both technical innovation and practical implementation.

• Microscopy Today Innovation Award (2013)

Professor Hoogenboom actively supervises students and has developed educational materials including an interactive textbook on electricity and magnetism. His lab collaborates extensively with industry partners and end users to translate technological advances into practical applications for life sciences, health, and materials research. The Hoogenboom Lab operates at the interdisciplinary intersection of physics, engineering, chemistry, and biology.