معرفی
Isabelle Mansuy is Full Professor of Neuroepigenetics at the Department of Health Sciences and Technology at ETH Zurich and holds a dual appointment at the Brain Research Institute of the Medical Faculty of the University of Zurich. She serves as Deputy Head of the Institute for Neuroscience at ETH Zurich and Co-Director of both the Brain Research Institute (UZH) and Institute for Neuroscience (ETHZ).
Her educational background includes:
- Degrees in Biotechnology Engineering and Molecular Biology from Université Louis Pasteur and École Supérieure de Biotechnologie de Strasbourg
- European PhD in Molecular and Developmental Neurobiology from Université Louis Pasteur (1994)
- Postdoctoral training at Columbia University's Center for Neurobiology and Behavior with Eric Kandel
Mansuy's research focuses on the epigenetic basis of complex brain functions and the transgenerational transmission of acquired behaviors in mammals. Her laboratory employs a multidisciplinary approach combining epigenetic and genetic methods, behavioral testing, multi-omics techniques, bioinformatics, and imaging. Key research areas include:
- Epigenetic inheritance of trauma-induced traits across generations
- Neuroepigenetic mechanisms of memory formation and forgetting
- Chromatin organization in brain and germ cells
- Early life stress effects on mental and physical health
- Development of potential diagnostic and therapeutic tools for trauma patients
Analysis of her recent publications reveals a strong focus on transgenerational epigenetic inheritance, particularly examining how early life stress affects germ cells and leads to behavioral and physiological changes across multiple generations. Her work increasingly incorporates multi-omics approaches to identify molecular signatures of trauma in both animal models and human subjects.
Her scientific honors include:
- Election to the European Academy of Sciences (2017)
- Knight in the Order of the Legion of Honour, France (2016)
- Membership in the Research Council of the Swiss National Science Foundation (2011)
- EMBO membership (2006)
- Multiple prestigious research awards including the Robert Bing Prize (2008)
Mansuy has supervised numerous PhD students and postdoctoral fellows, contributing significantly to training the next generation of neuroscientists. Her research has been supported by major funding agencies including the Swiss National Science Foundation. She leads an active laboratory with multiple ongoing projects exploring different aspects of epigenetic memory and inheritance, including epigenetic memory in the germline, soma-to-germline communication, and the impact of stress on chromatin organization.
The Mansuy Lab maintains strong collaborations with clinicians to translate findings from mouse models to human trauma patients, particularly focusing on childhood trauma effects. The lab also collaborates with the Mateescu Group, which specializes in RNA biology and extracellular RNA research.
