معرفی
Isabelle Laverdière is an Associate Professor at the Faculty of Pharmacy, Laval University, where she conducts research focused on optimizing therapies in pediatric oncology. Her work integrates pharmacogenomics, pharmacokinetics, and clinical pharmacy interventions to improve drug efficacy and reduce toxicity in children with cancer. She is actively involved in teaching both undergraduate and graduate courses in pharmaceutical sciences.
Research Interests:
- Pharmacology in Pediatric Oncology
- Pharmaco(epi)genomics and Pharmacogenomics Implementation
- Predictive Biomarkers for Drug Response and Toxicity
- Clinical Pharmacy Interventions in Cancer Care
- Personalized Medicine and Therapeutic Optimization in Leukemia
Her recent publications emphasize the role of genetic and epigenetic markers in predicting chemotherapy outcomes, particularly in acute leukemias and solid tumors. Themes across her work include stem cell biology, immune pathway involvement in cancer, and translational applications of genomic data to tailor treatments. She has contributed to understanding drug metabolism pathways and transporter polymorphisms affecting irinotecan toxicity, as well as the integration of pharmacogenetics into clinical pharmacy practice.
Scientific Grants:
- Immunophenotyping infrastructure for functional pharmacoEPIgenomics of childhood leukemia (CFI-FLJR, 2018–2020)
- Optimisation des thérapies en leucémie aiguë pédiatrique (FRQS, 2019–2023)
- Pharmacogene methylation profiling during acute lymphoblastic leukemia treatment (SRC, 2018–2020)
- Développement d’une intervention visant à favoriser l’adhésion à la chimiothérapie orale chez les enfants atteints de leucémie lymphoblastique aiguë (CHU de Québec-UL, 2018–2019)
- Elucidation of the functional rôle of Complement Factor D in Acute Myeloid Leukemia (Leukemia & Lymphoma Society of Canada, 2017–2018)
She supervises multiple graduate students in pharmaceutical sciences and co-supervises advanced pharmacotherapy students. Her training includes a postdoctoral fellowship at the Research Institute of the McGill University Health Center and doctoral and master’s degrees in pharmacy and pharmaceutical sciences from Laval University. She leads a research team focused on advancing precision medicine in pediatric cancer therapy.
