معرفی
Isabella Moll is a Professor at the Max Perutz Labs, Department of Microbiology, Immunobiology and Genetics. Her research focuses on bacterial gene expression regulation, particularly under stress conditions, with an emphasis on translation initiation mechanisms, leaderless mRNAs, and the MazF toxin-antitoxin system. She has contributed extensively to understanding how bacteria adapt to stress through translational control and RNA processing. Her work integrates structural biology, molecular genetics, and systems biology approaches.
Key research areas include the study of ribosome heterogeneity induced by stress, the role of small RNAs in regulating gene expression, and the molecular mechanisms underlying bacterial persistence and antibiotic resistance. She has led projects funded by grants such as 'Translation initiation complex formation during stress' and 'S1:Neue Mechanismen Stressantwo'.
Her collaborations span international institutions, reflecting her expertise in bacterial stress responses and protein synthesis. Notable contributions include elucidating the function of MazF in translational heterogeneity and the role of RNA ligases in reversing ribosome abnormalities. She has also explored quorum sensing mechanisms and the impact of antibiotics like kasugamycin on bacterial physiology.
Her work aligns with UN Sustainable Development Goals, particularly in combating antimicrobial resistance and advancing molecular biology insights for health and environmental sustainability.
