Isabella Caterina Felli

Isabella Caterina Felli is an Associate Professor in the Department of Chemistry at the University of Florence, where she is affiliated with the Magnetic Resonance Center (CERM). Her research focuses on the development and application of NMR spectroscopy to study intrinsically disordered proteins (IDPs) and their role in human diseases such as cancer and neurodegenerative disorders.

Dr. Felli's research centers on intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), investigating how protein flexibility enables biological function despite lacking stable 3D structures. She pioneers advanced NMR methodologies including in-cell NMR, 13C direct-detection techniques, and paramagnetic relaxation enhancement to characterize dynamic protein behavior under near-physiological conditions. Her work bridges structural biology and disease mechanisms, aiming to identify novel drug targets for currently incurable disorders.

Her publication record from 2013-2020 reveals consistent innovation in NMR methodology for IDP studies, with recurring themes in long-range contact characterization, polyglutamine tract behavior, and proline residue dynamics. Key methodological advances include CON-CON assignment strategies for flexible proteins and in-cell 13C NMR protocols, demonstrating her leadership in pushing technical boundaries for observing proteins in native-like environments.

Dr. Felli's scientific awards and honors are not detailed in the provided information.

While the available text does not list specific students advised by Dr. Felli, her role as Associate Professor and co-author on numerous publications with junior researchers suggests active mentorship of graduate students. Information regarding grant funding sources and amounts is not provided in the current source material.

Dr. Felli is a core researcher at the Magnetic Resonance Center (CERM) in Florence, where she leads NMR-based investigations of disordered proteins. She maintains a highly collaborative research program, evidenced by frequent co-authorship with Professor Roberta Pierattelli and international teams across Europe. Her work significantly contributes to CERM's reputation in structural biology and supports the center's mission in integrated biomolecular research.