معرفی
Irina M. Bochkis, Ph.D., serves as Associate Professor in the Department of Pathology at the University of Pittsburgh School of Medicine and leads research at the Pittsburgh Liver Research Center. Her program investigates molecular mechanisms linking epigenetic regulation to liver metabolism and metabolic diseases including diabetes and MASLD.
Her educational background includes a BS in Chemical Engineering from Princeton University and a PhD in Genomics & Computational Biology from the University of Pennsylvania.
Dr. Bochkis's research spans liver metabolism, epigenetic regulation, and chromatin dynamics, with emphasis on pioneer factor Foxa2's role in nuclear receptor signaling. Her lab employs integrated experimental and computational approaches to study chromatin accessibility, nuclear architecture, and genome organization in metabolic disease models.
Analysis of her 2020-2024 publications reveals consistent focus on Foxa2-mediated chromatin conformation changes in nonalcoholic fatty liver disease, demonstrating expertise in bridging molecular mechanisms with physiological outcomes through functional genomics.
No scientific awards are documented in the provided information.
Dr. Bochkis actively mentors graduate and undergraduate students, as evidenced by recent lab milestones, and secures competitive funding including an NIDDK R01 grant (DK121059) supporting her work on chromatin dynamics in metabolic disease.
The Bochkis Lab operates within the Pittsburgh Liver Research Center and pursues three synergistic projects on pioneer factors, nuclear lamina regulation, and novel hepatic steatosis regulators, maintaining a collaborative environment highlighted by annual appreciation events.
