Ioannis Trougakos

Ioannis Trougakos leads the "Ageing and Age-Related Diseases" research group at the Department of Cell Biology and Biophysics, Faculty of Biology, National & Kapodistrian University of Athens (NKUA). His work focuses on aging biology, proteostasis, and systemic disease mechanisms using multidisciplinary systems biology approaches.

• Founded in 1932 and reformed in 1990, NKUA's Faculty of Biology is Greece's top-ranked biology faculty, offering cutting-edge postgraduate programs.
• The lab utilizes advanced facilities including cryo-electron microscopy, confocal imaging, and high-throughput screening platforms.

Research spans:

• Proteostatic and mitostatic regulatory networks
• Metabolic-genomic cross-talk
• Tissue-organismal communication in aging
• Small molecule discovery for anti-aging/anti-cancer applications
• Mechanisms of proteasome inhibitor toxicity
• Vaccination responses in comorbid populations

Recent publications highlight expertise in NRF2 signaling, oxidative stress, and molecular aging. The lab employs 4 postdocs, 3 PhD, 3 MSc, and 6 BSc students. Funding comes from European Union programs, Hellenic foundations, and industry partnerships.