Anne Bertolotti

Anne Bertolotti is a Research Professor at the University of Cambridge, affiliated with the MRC Laboratory of Molecular Biology (MRC-LMB). Her research focuses on understanding cellular resilience mechanisms in neurodegenerative diseases, particularly the role of protein misfolding and proteostasis in Alzheimer’s, Parkinson’s, Huntington’s, and ALS.

• Research: Investigates proteasome homeostasis, phosphatase inhibition, and stress responses to mitigate protein misfolding pathologies.
• Email: aberto@mrc-lmb.cam.ac.uk

Her work has been recognized through Editor’s Choice and Research Highlights in journals like Science, Nature Chemical Biology, and Nature Reviews Drug Discovery, including a Faculty of 1000 recommendation (2015). Key publications span studies on phosphatase regulators, proteasome adaptation, and prion-like propagation of misfolded proteins. The lab’s recent efforts include identifying small molecules to target proteostasis pathways and elucidating mechanisms of proteasome dysfunction in aging.