Ingrid Aass Roseth

Ingrid Aass Roseth is a Researcher at the Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), based at Gastrosenteret, Øya. Her research centers on multiple myeloma pathogenesis with emphasis on bone marrow microenvironment interactions and tumor progression mechanisms.

Education:

• PhD in Medicine (expected 2025), Norwegian University of Science and Technology

Her research integrates Oncology, Immunology, and Molecular Biology to investigate how obesity, Toll-like receptor signaling, and cytokines like IL-32 modulate malignant plasma cell behavior. Key approaches include Vk*MYC mouse modeling and mass cytometry to dissect spatial cellular relationships in bone marrow niches, revealing obesity-induced suppression of immune surveillance and pro-survival signaling pathways.

Recent publications demonstrate consistent focus on microenvironmental drivers of myeloma: diet-induced obesity reduces bone marrow lymphocytes to accelerate tumor growth, Toll-like receptors upregulate BCL2/MYC to enhance tumor survival, and IL-32 governs mitochondrial metabolism in plasma cells. These findings highlight therapeutic targets in the tumor-stromal interface.

Dr. Roseth actively disseminates findings through international conferences including the Nordic Myeloma Study Group Meeting and Norwegian Flow Cytometry events. She collaborates within NTNU's hematology research cluster led by Siv Helen Moen, utilizing advanced imaging cytometry to map cellular interactions in myeloma progression.