Igor Makhlin

Igor Makhlin, MD is an Assistant Professor of Clinical Medicine in the Department of Hematology-Oncology at the Perelman School of Medicine, University of Pennsylvania. He practices at Penn Medicine with clinical locations at the Abramson Cancer Center Radnor and the Perelman Center for Advanced Medicine (Rena Rowan Breast Center). Dr. Makhlin specializes in medical oncology with a focus on breast cancer treatment and maintains hospital privileges at the Hospital of the University of Pennsylvania.

Dr. Makhlin's research focuses on critical areas in breast cancer including prevention of recurrence through targeting dormant tumor cells, understanding mechanisms of therapeutic resistance, evaluating novel antibody-drug conjugates, and examining cardiovascular effects of cancer therapies. His work spans basic science investigations, clinical trials, and translational research aimed at improving patient outcomes.

His publication record shows consistent productivity with numerous high-impact papers from 2020-2025 in journals including Nature Medicine, Clinical Cancer Research, and Journal of Clinical Oncology. His research demonstrates particular expertise in metastatic breast cancer, treatment resistance mechanisms, and innovative clinical trial design.

Dr. Makhlin completed his medical education at Geisinger Commonwealth School of Medicine, residency at Johns Hopkins Hospital, and fellowship at the Hospital of the University of Pennsylvania. His clinical practice serves patients aged 18 and older, and patient reviews consistently rate him 5.0 out of 5 for his knowledge, attentiveness, and patient-centered approach.