David H. Henry

David H. Henry, MD, serves as Clinical Professor of Medicine and Vice Chair of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. He maintains active clinical practice through Penn Medicine at Pennsylvania Hospital and the Radnor campus, specializing in hematology-oncology with hospital privileges at both Hospital of the University of Pennsylvania and Pennsylvania Hospital. His work integrates academic leadership with direct patient care in complex cancer cases.

Dr. Henry's research spans critical areas in hematology-oncology, with significant contributions to national treatment standards. His expertise in Kaposi Sarcoma and cancer in HIV-positive patients informs NCCN Clinical Practice Guidelines, while clinical investigations address anemia management in bloodless medicine and pregnancy. Recent work on myelodysplastic syndromes (MATTERHORN trial) and bone metastases demonstrates translational impact across solid tumors and hematologic malignancies.

Analysis of his 2024-2025 publications reveals a strategic focus on optimizing treatment protocols for vulnerable populations: immunocompromised patients, those requiring blood conservation, and biomarker-defined cancer subgroups. His commentaries on EGFR-targeted therapies in NSCLC and bone-targeting agents highlight expertise in integrating novel therapeutics into clinical practice through evidence synthesis.

As Vice Chair of Medicine, Dr. Henry oversees academic and clinical operations while maintaining active patient care. His leadership facilitates collaboration between the Abramson Cancer Center, Department of Medicine, and Penn Medicine's hospital network, supporting clinical trial enrollment and multidisciplinary cancer care. Patient reviews consistently rate him 4.9/5.0 for clinical expertise and communication skills.

Dr. Henry's clinical practice operates through two primary locations:

• Penn Hematology/Oncology at Pennsylvania Hospital (Abramson Cancer Center)
• Penn Medicine Radnor (145 King of Prussia Road)

He accepts new adult patients and manages complex cases requiring specialized hematology-oncology expertise, particularly in HIV-associated malignancies and blood disorder management.