معرفی
Hilde Loge Nilsen is a Professor at the Department of Clinical Molecular Biology, University of Oslo, and holds dual roles as a Researcher and problem-based learning supervisor at the Medical Faculty. She leads the 'DNA Repair' group and has affiliations with the Biotechnology Centre of Oslo and the research group 'Genome instability in ageing and disease'.
Her education includes a Dr. ing. from NTNU (2000) and postdoctoral work at Cancer Research UK (2000–2004). Key research interests focus on DNA/RNA quality control mechanisms in disease, particularly their roles in cancer, neurodegeneration, and aging. Her work bridges DNA repair’s traditional mutation-prevention role with its emerging functions in neurobiology and RNA integrity.
Her research achievements include identifying uracil accumulation mutation signatures, linking DNA repair defects to neurodegeneration, and discovering SMUG1’s role in RNA quality control. Recent studies emphasize NAD+’s role in mitigating neurodegeneration and mitochondrial dysfunction.
Collaborations span academic and clinical institutions, with contributions to understanding autophagy induction and transcriptomic compensation in DNA repair-deficient organisms. She actively supervises medical education and contributes to interdisciplinary research teams.
