معرفی
Professor Hilde Nilsen is affiliated with the Department of Clinical Molecular Biology at the University of Oslo and Akershus University Hospital. Her research focuses on the intersection of DNA repair, aging, and neurodegenerative diseases using Caenorhabditis elegans models, with additional work in precision oncology and mitochondrial biology.
- Education:
- MSc in Biochemical Engineering
- PhD from Norwegian University of Science and Technology
- Post-doctoral training with Nobel laureate Tomas Lindahl
Her research explores how DNA repair mechanisms drive neurodegeneration and aging, combining genetic approaches with multi-level phenotyping. Key areas include mitochondrial dysfunction, RNA quality control, and the role of NAD+ in aging and disease. She developed the first C. elegans laboratory in Norway and reconstituted Base Excision Repair on nucleosomal substrates.
Recent publications highlight her work in precision oncology, Parkinson's disease, DNA glycosylases, and mitophagy. She investigates aging-related cancer mechanisms, biomarker development, and interventions like nicotinamide riboside.
Scientific contributions include:
- Establishing C. elegans models for neurodegeneration
- Defining roles of RNA repair enzymes
- Investigating NAD+ in longevity and mitochondrial health
As a supervisor, she leads projects on bioscience modeling of brain aging. Her work integrates national and international collaborations, including Norway–UK aging research initiatives.
