معرفی
Hendrik Harms is a Postdoctoral Researcher (Research Fellow) in the Department of Drug Design and Pharmacology at the Faculty of Health and Medical Sciences, University of Copenhagen, with research focusing on ion channel biophysics and protein engineering. His work investigates sodium channel regulation by G protein-coupled receptors, phosphorylation mechanisms, and disease-causing mutations using advanced biochemical and computational techniques.
His research spans ion channel biophysics, molecular pharmacology, and cardiac electrophysiology, emphasizing structure-function relationships in sodium channels (NALCN and Nav1.5). He employs protein semi-synthesis, molecular dynamics simulations, and trans-splicing methodologies to dissect channel dysfunction in neurological and cardiac disorders, bridging fundamental biochemistry with therapeutic applications.
Analysis of his 2020-2023 publications reveals a cohesive research trajectory centered on sodium channel pathophysiology, with increasing emphasis on engineering approaches for channel modification. His work integrates biophysical, computational, and protein engineering disciplines to elucidate mutation-phosphorylation cross-talk and develop novel tools for ion channel manipulation, demonstrating strong interdisciplinary collaboration.
Dr. Harms operates within the Department of Drug Design and Pharmacology at the University of Copenhagen, maintaining active collaborations with Sørensen A. Pless's research group and international partners on ion channel structure-function studies and protein engineering applications.
