معرفی
Prof. Hemmo Meyer is a Professor at the University of Duisburg-Essen, leading the Molecular Biology I group within the Center of Medical Biotechnology (ZMB) in the Faculty of Biology. His research focuses on cellular stress responses, proteostasis, and the roles of the ubiquitin-proteasome system (UPS) and autophagy in maintaining cellular homeostasis. He explores how the AAA+-type ATPase VCP/p97 governs processes like ER-associated degradation, DNA damage repair, and lysophagy, particularly in contexts of degenerative diseases and cancer therapy. He is also the speaker of the Collaborative Research Center (CRC) 1430 and contributes to EU and NRW funding programs. His lab distributes plasmids via Addgene.org.
Research interests include deciphering molecular mechanisms of stress-induced cell death and aging-related degeneration. Key areas involve the UPS’s coordination with cell cycle pathways, lysosomal damage sensing, and the structural biology of VCP/p97 complexes. His work bridges basic science and translational research, targeting VCP/p97’s role in diseases like ALS and FTD. Recent studies highlight discoveries of signaling pathways involved in lysosomal repair and autophagy, such as SPG20-ITCH-mediated lysophagy and UBE2QL1’s coordination of cellular responses to endolysosomal damage.
Prof. Meyer collaborates extensively, working with researchers on projects ranging from structural biology to drug development. His contributions include identifying VCP/p97’s role in nuclear assembly and spindle disassembly, as well as its interactions with kinases like Aurora B. His lab’s methods span biochemistry, cell biology, and nanotechnology, including the use of calcium phosphate nanoparticles and DNA origami systems for studying cellular processes.
