معرفی
Hayley Muendlein is a Research Assistant Professor in the Department of Immunology at Tufts University School of Medicine. Her work focuses on understanding the molecular mechanisms regulating cell death pathways, particularly necroptosis and pyroptosis, and their crosstalk with inflammatory signaling. She investigates how proteins like RIPK1, cFLIP, and ZBP1 coordinate host defense responses against pathogens while preventing excessive inflammation.
Education:
- PhD in Immunology, Tufts University (2015–2020)
- B.A. in Biology, Franklin and Marshall College (2010–2014)
Research Highlights: Dr. Muendlein’s research reveals how ZBP1 links bacterial LPS sensing to RIPK1-dependent cell death, and how CFLIPL inhibits pyroptosis in macrophages. Her work uses mouse models of endotoxin shock and Yersinia infection to study cell death’s role in survival outcomes. She has identified non-canonical RIPK1 autophosphorylation as a critical regulator of pyroptosis timing during infections.
Publications: Her 14+ articles (2018–2024) span Cell Reports, Science Immunology, and PNAS, emphasizing RIPK1 signaling, ZBP1 function, and inflammatory cytokine regulation. Key findings include the role of CD14 in TNF lethality and LFA-1’s role in T cell signaling.
Advising & Grants: While specific grant details are not listed, her postdoctoral training under Dr. Poltorak (2020–2022) suggests NIH-funded work. No formal advisee list is provided, but her publications include collaborative research teams.
Labs/Teams: Works within the Poltorak Lab at Tufts, focusing on cell death mechanisms in innate immunity.
