Alexei Degterev

Alexei Degterev is an Associate Professor at Tufts University School of Medicine in the Department of Developmental, Molecular and Chemical Biology. His research focuses on the molecular mechanisms of regulated cell death, particularly necroptosis and apoptosis, and their roles in human disease pathologies including cancer, inflammatory diseases, and neurodegeneration. He develops chemical probes and drug leads targeting RIPK1/3 kinases to modulate cell death processes.

• BSc in Chemistry from Moscow State University (1991)
• MSc in Biochemistry from Moscow State University (1993)
• PhD in Biochemistry from Boston University (1998)

His research explores:

• Regulated cell death mechanisms
• RIPK1/3 kinase signaling pathways
• Innate immune responses in inflammation
• Drug discovery for inflammatory diseases
• Collaborative development of kinase inhibitors

Recent publications highlight work on:

• Cardiac reperfusion injury
• AI in drug screening
• Yersinia infection responses
• Influenza-associated lung injury
• RIPK3 genetic inhibition in brain trauma

Notable awards include multiple NIH grants for research on:

• RIPK3 inhibitors in influenza
• RIPK1 signaling in multiple sclerosis
• Necroptosis in cardiac injury
• Kinase biology in inflammatory disease

He teaches graduate courses in:

• Biochemistry
• Cell biology
• Translational pharmacology
• Molecular recognition
• Neuroscience foundations