معرفی
Hannah L. Klein is a Research Professor in the Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine, New York University, with a research focus on DNA damage repair mechanisms and genomic instability. Her work bridges molecular genetics and cancer biology through innovative yeast-based models.
Her academic credentials include:
- PhD from University of Washington
Dr. Klein's research program centers on fundamental DNA maintenance processes:
- Pathways of DNA damage avoidance
- DNA repair and recombination mechanisms
- Genomic instability origins
- DNA damage checkpoint signaling
- Cancer-related genomic alterations
She pioneered investigations into ribonucleotide incorporation in DNA, elucidating how RNase H2, topoisomerases, and helicases prevent mutagenesis. Her laboratory employs Saccharomyces cerevisiae to dissect evolutionarily conserved mechanisms relevant to human disease.
Analysis of her 81 publications reveals consistent emphasis on ribonucleotide-induced genomic stress, with recent work (2021-2025) expanding into rDNA topology, recombination dynamics, and the dual nature of ribonucleotide lesions. These studies integrate molecular biology, biochemistry, and genetics to address fundamental questions in genome integrity.
