Gregory L Sahlem

Dr. Gregory L Sahlem is an Associate Professor in the Department of Psychiatry and Behavioral Sciences at Duke University. Board-certified in general psychiatry and addiction medicine, he specializes in interventional psychiatry with advanced training in treating addictive, mood, and sleep disorders. His translational research focuses on developing circuit-based treatments for mood and substance use disorders.

• K23 Mentored Clinical Scientist Program, Medical University of South Carolina (2017-2022)
• K12 Mentored Clinical Scientist Program, Medical University of South Carolina (2015-2017)
• Interventional Psychiatry Fellowship, Medical University of South Carolina (2014-2015)
• Psychiatry Residency, Medical University of South Carolina (2010-2014)
• M.D., University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2010)

Dr. Sahlem's research spans neuromodulation techniques like repetitive transcranial magnetic stimulation (rTMS) and electroconvulsive therapy (ECT), targeting brain circuits in cannabis use disorder, nicotine dependence, treatment-resistant depression, Parkinson's disease depression, and autism comorbidities. His work explores neurostimulation's impact on craving reduction, cortical thickness modeling, and multimodal treatment combinations.

Recent publications highlight advancements in cannabis cue-reactivity fMRI paradigms, theta-burst TMS for inhibitory control, FEAST vs ECT comparative trials, and cortical stimulation optimization for depression. His academic output demonstrates cross-disciplinary integration between clinical neuroscience, addiction medicine, and neurotechnology development.

• K23 Mentored Clinical Scientist Program
• K12 Mentored Clinical Scientist Program

Dr. Sahlem actively contributes to clinical research grants, including "The Development and Validation of Neural Targets in Opioid Use Disorder for Use Across Addictions" (2024-2027). His work combines active clinical practice with translational research, bridging neuroimaging findings to therapeutic interventions for substance use and mood disorders.