معرفی
Giovanni Ligresti is an Associate Professor at Boston University's Chobanian & Avedisian School of Medicine, affiliated with the Pulmonary Center. He holds a PhD from the University of Trieste and mentors graduate students in medical sciences. His research focuses on molecular mechanisms of lung repair and pulmonary fibrosis, particularly the role of epigenetic modifiers like CBX5 and G9a in fibroblast activation. He investigates how aging impacts vascular dysfunction and persistent fibrosis, using multi-omics approaches including RNA-seq and scRNA-seq. Ligresti leads NIH-funded grants targeting vascular dysfunction and epigenetic pathways in fibrosis. His work bridges basic science and translational medicine, addressing key questions in fibrotic disease mechanisms and therapeutic strategies.
Education: PhD, MS, BS in Biology from University of Trieste.
Research Interests: Lung fibrosis, epigenetic regulation, aging mechanisms, vascular biology, and regenerative medicine. Key projects include identifying therapeutic targets for idiopathic pulmonary fibrosis and understanding aging-associated fibrosis through endothelial cell dysfunction.
Grants: Principal Investigator (PI) on NIH R01 grants (HL158733, HL142596) and industry funding from Ono Pharmaceutical. Subcontract PI on NHLBI-funded research.
Labs/Teams: Leads labs at the Pulmonary Center, collaborating with teams on lung injury models and omics-based discovery.
