معرفی
Professor Gil Privé is a structural biologist in the Department of Biochemistry at the University of Toronto and a Senior Scientist at the Princess Margaret Cancer Centre. His research focuses on understanding protein structure and molecular recognition, particularly in transcriptional repression complexes, ubiquitin ligase systems, and sphingolipid metabolism.
- Education: PhD from UCLA under Richard Dickerson (x-ray crystallography/DNA structure); postdocs at UC Berkeley (Sung-Hou Kim) and UCLA (David Eisenberg, Ron Kaback).
His lab employs biophysics and structural biology to study:
- BTB-zinc finger transcriptional regulators in cancer development
- Cullin3-Ring-Ligase (CRL3) assembly for ubiquitination
- Saposin proteins in sphingolipid metabolism and signaling
Key trends in his publications (2003–2020) include:
- Atomic-level characterization of protein-protein/peptide/lipid interactions
- Structural basis for oncogenic processes (e.g., BCL6, DLBCL)
- Development of novel tools for membrane protein analysis (picodiscs, lipopeptide detergents)
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