معرفی
George Q. Daley, MD, PhD, serves as Dean of Harvard Medical School and holds the Caroline Shields Walker Professorship of Medicine. He is a Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, with extensive affiliations including the Harvard Stem Cell Institute, Broad Institute of MIT and Harvard, and the Manton Center for Orphan Disease Research at Boston Children's Hospital.
Daley's research focuses on using mouse and human disease models to identify mechanisms underlying blood disorders and cancer. His laboratory aims to define fundamental principles of stem cell contributions to tissue regeneration and repair, with applications for improving drug and transplantation therapies for patients with malignant and genetic bone marrow diseases. His work spans stem cell biology, cancer research, hematopoiesis, and regenerative medicine.
Analysis of his recent publications reveals a consistent focus on stem cell applications in disease modeling, with particular emphasis on hematopoietic development, immunotherapy applications, and the translation of basic research into clinical applications. His work increasingly incorporates advanced technologies including single-cell analysis and genetic engineering approaches.
- NIH Director's Pioneer Award (2004)
- Judson Daland Prize from American Philosophical Society
- E. Mead Johnson Award from American Pediatric Society
- E. Donnall Thomas Prize from American Society of Hematology
- Janet Rowley Prize from International Chronic Myeloid Leukemia Foundation
- HMS A. Clifford Barger Excellence in Mentoring Award (2012)
Daley has trained dozens of graduate students and postdoctoral fellows throughout his career. He has served in leadership roles for the International Society for Stem Cell Research, including as president (2007-08), and has been instrumental in developing international guidelines for stem cell research. His laboratory has made significant contributions to the field, including creating customized stem cells for treating genetic immune deficiencies and demonstrating the role of the LIN28/let-7 pathway in cancer.
Daley leads research initiatives focused on stem cell applications for blood disorders and cancer treatment, with particular emphasis on translating basic discoveries into clinical applications through collaborations with the Dana-Farber Cancer Institute and Boston Children's Hospital.
