George Bloom

George Bloom is a Professor in the Department of Biology, Cell Biology, and Neuroscience at the University of Virginia. His research focuses on Alzheimer’s disease (AD) and tauopathies, specifically examining the roles of amyloid-β (Aβ) and tau oligomers in neurodegeneration. Bloom's work explores how these proteins disrupt neuronal functions, including microtubule integrity, mitochondrial activity, and cell cycle regulation, with implications for developing diagnostic and therapeutic tools for AD.

• University of Virginia
• Department of Biology, Cell Biology, and Neuroscience

Research interests include:

• Alzheimer’s disease pathogenesis
• Tau and amyloid-beta oligomer toxicity
• Neuronal cell cycle re-entry
• Lysosome-mitochondria signaling
• Precision biomarkers for tauopathies
• Therapeutic target identification

Bloom's recent publications analyze:

• 2023 study on tau phosphorylation at threonine 217 in Alzheimer's pathology
• 2018 discoveries about lysosome-to-mitochondria signaling disruption
• 2017 work on mTOR pathway activation in neurodegeneration
• 2014 theoretical framework of Aβ as trigger and tau as effector in AD