Geoffrey Manley

Geoffrey Manley, MD, PhD, is Professor and Vice Chairman of Neurological Surgery at the University of California, San Francisco (UCSF) School of Medicine. He serves as Chief of Neurosurgery at Zuckerberg San Francisco General Hospital and Co-Director of the Brain and Spinal Injury Center (BASIC). His clinical and research focus centers on traumatic brain injury (TBI), spanning molecular mechanisms, biomarker development, and clinical care optimization.

Education and Training

• Postdoc Fellowship in Molecular Biophysics, UCSF (1999)
• MD, Cornell University Medical College (1995)
• Postdoc Fellowship in Neuroscience, Memorial Sloan Kettering Cancer Center (1995)
• PhD in Neuroscience, Cornell University (1994)
• BS in Biology, University of Kentucky (1988)

Research Focus

Dr. Manley leads translational research developing diagnostic/prognostic models for TBI through major initiatives like TRACK-TBI (NIH/DoD-funded) and the TBI Endpoints Development (TED) Initiative. His work integrates laboratory neuroscience with clinical data repositories to advance precision medicine in neurotrauma. Key research domains include:

• Biomarker validation for injury stratification
• Multicenter clinical trial design
• Neuroimaging-pathology correlations
• Long-term outcome prediction models

Publication Trends

His recent articles (2023-2025) demonstrate a focus on standardizing TBI classification through NIH-NINDS initiatives, validating blood biomarkers (GFAP, UCH-L1, Tau), and optimizing clinical pathways. Over 70% of publications involve multicenter collaborations, emphasizing:

• Diagnostic protocol refinement
• Health disparities in TBI care
• Neuropsychiatric sequelae
• Data-driven prognostic modeling

Grants and Leadership

As Principal Investigator for $30M+ in active funding, his portfolio includes:

• TRACK-TBI Network (DoD MTEC2018-674)
• TRACK-TBI Precision Medicine (DoD W81XWH-18-2-0042)
• TED Initiative (DoD W81XWH-14-2-0176)
• Analytical Validation of Tau Biomarkers (NIH U01NS111680)

He co-leads the NIH-NINDS TBI Classification Initiative, shaping global research standards.

Clinical and Institutional Roles

Dr. Manley oversees trauma neurosurgery at Zuckerberg SF General and directs the BASIC translational research hub. His team collaborates with 18 TRACK-TBI sites to integrate acute care with rehabilitation science.