Gabriel Sosne

Gabriel Sosne, MD, is Associate Professor of Ophthalmology, Visual and Anatomical Sciences at Wayne State University School of Medicine and a clinician-scientist at the Kresge Eye Institute, where he specializes in comprehensive ophthalmology with emphasis on cataract surgery, corneal and ocular surface wound healing, and dry eye disease.

Education & Training

• MD – Albert Einstein College of Medicine, Bronx, NY
• Ophthalmology Residency – Henry Ford Hospital, Detroit, MI
• Research Fellowship – Howard Hughes Medical Institute, Chevy Chase, MD
• Clinical Fellowship – National Institutes of Health, Bethesda, MD
• Board Certification – American Board of Ophthalmology

Research Focus
Dr Sosne’s research is centered on translating the regenerative peptide thymosin β4 into clinically approved therapies. His laboratory elucidated the molecular mechanisms by which thymosin β4 suppresses NF-κB–driven inflammation, accelerates corneal epithelial migration, and prevents apoptosis in injured ocular surface tissues. These insights have advanced Phase II and III clinical trials that evaluate thymosin β4 eye drops for dry-eye disease and neurotrophic corneal ulcers, positioning the peptide as a first-in-class ocular wound-healing agent.

Publication Landscape
Across more than 37 peer-reviewed papers (2002–2024), Dr Sosne’s publications trace a clear translational arc from basic peptide biology to definitive clinical trials. Early mechanistic studies defined critical residues within thymosin β4 that confer anti-inflammatory and pro-reparative activities, whereas later trials-based reports document accelerated healing of neurotrophic corneal defects and significant symptom relief in dry-eye patients. The collective literature underscores a consistent therapeutic theme: thymosin β4 drives resolution of ocular surface inflammation while promoting rapid, high-quality tissue regeneration.

Professional Memberships & Recognition

• Member, American Academy of Ophthalmology
• Member, Association for Research in Vision and Ophthalmology (ARVO)

Clinical & Research Integration
Operating at the intersection of patient care and bench research, Dr Sosne maintains active clinical practices in Detroit and Bingham Farms, ensuring that unmet clinical needs continuously inform his investigative agenda. He is the principal investigator on federal and industry-sponsored clinical trials evaluating thymosin β4 for ocular surface disease, and he mentors residents, fellows, and graduate students within the Kresge Eye Institute’s vision research community.

Laboratory & Team
Dr Sosne heads a translational research laboratory embedded within the Kresge Eye Institute. The team integrates corneal cell biologists, clinical coordinators, and imaging specialists who collectively advance peptide-based therapies from molecular concept to bedside application.