معرفی
Frederick Maxfield, PhD, is the Vladimir Horowitz and Wanda Toscanini Horowitz Distinguished Professor in Neuroscience and Professor of Biochemistry at Weill Cornell Medical College. He holds a PhD (1977) and MS (1973) from Cornell University, and a BS (1971) from Union College. His research focuses on cellular imaging and biophysical techniques to study lipid metabolism, membrane dynamics, and macrophage function in cardiovascular and neurodegenerative diseases.
Research Interests: His lab investigates cholesterol trafficking, lysosomal function, and extracellular digestion processes in diseases like atherosclerosis and Alzheimer's. Key areas include the role of STARD4 and NPC1 proteins in sterol transport, microglial clearance of amyloid-beta, and high-throughput drug screening platforms.
Publications: Recent work highlights novel imaging probes (ApHID), pharmacological chaperones for NPC1 disease, and mechanisms of macrophage lipid catabolism. Over 300 peer-reviewed articles reflect expertise in cellular imaging, lipid metabolism, and neuroinflammation.
Awards/Grants: Active grants include NIH-funded studies on STARD4 in foam cell formation (American Heart Association), lysosomal roles in amyloid degradation (NIA), and NPC1 treatment strategies (ARA Parseghian Foundation).
Labs/Teams: The Maxfield Lab collaborates on microscopy-based drug discovery and lipid biology, with ongoing projects on macrophage-lipoprotein interactions and neurodegenerative mechanisms.
