معرفی
Francesca Persichetti is an Associate Professor in the Department of Health Sciences at the University of Eastern Piedmont, where she leads research on molecular mechanisms of neurodegenerative diseases with a focus on RNA biology and genetic pathways.
Her primary research spans Neurodegenerative Diseases, Molecular Biology, and RNA Biology, with specialized expertise in Huntington's Disease and non-coding RNA systems. She investigates how LINE-1 retrotransposons regulate cortical development, how SINEUP non-coding RNAs depend on RNA modifications like N6-methyladenosine, and the neurotoxic role of neuronal hemoglobin in Parkinson's disease models. Her work integrates genomic, transcriptomic, and molecular approaches to uncover disease mechanisms.
Recent publications (2022-2023) reveal consistent focus on retrotransposon dysregulation in Huntington's disease, RNA modification-dependent gene regulation, and hemoglobin-induced neurodegeneration. These studies demonstrate interdisciplinary convergence of neuroscience, genetics, and molecular biology, with implications for therapeutic targeting of RNA pathways in neurodegeneration.
Scientific Awards:
- No specific awards mentioned in source materials
She secured two major research projects as Principal Investigator from MIUR (Italian Ministry of Education, University and Research): 'Genomica Funzionale delle Malattie Neurodegenerative' (2012-2018) exploring genomic bases of neurodegeneration, and 'Triggering neuroprotective pathways to prevent neurodegeneration' (2019-2023) investigating estrogen receptor beta/neuroglobin signaling in Huntington's disease. No student advising roles are documented in available records.
Her research group collaborates extensively with molecular neuroscience teams including Stefano Gustincich and Roberto Sanges, operating within the Department of Health Sciences framework. Current work focuses on RNA-mediated neuroprotective pathways and retrotransposon dynamics in disease models, contributing to UN Sustainable Development Goal 3 (Good Health and Well-being).
