Kyle Mansfield

Kyle Mansfield, Ph.D., serves as Associate Professor in the Department of Biochemistry and Molecular Biology at the Brody School of Medicine, East Carolina University. His research program bridges molecular biology, cancer research, and cellular response to environmental stressors.

Dr. Mansfield's research focuses on N6-methyladenosine (m6A) mRNA modification and its role in breast cancer progression and hypoxic response. His lab investigates how m6A levels change during cancer development, how RNA methyltransferases like METTL16 function, and how cells stabilize specific mRNAs during low oxygen conditions. This work has significant implications for understanding cancer biology and developing novel therapeutic approaches.

Analysis of recent publications reveals a clear research trajectory from foundational work on cellular oxygen sensing toward current focus on RNA epigenetics in disease. The lab's publications demonstrate expertise in molecular techniques for studying RNA modification, protein-RNA interactions, and cancer cell phenotypes.

Dr. Mansfield's research is supported by competitive funding including an American Cancer Society Research Scholar Grant and Brody Brothers Endowment Award, reflecting the significance and innovation of his work in RNA biology and cancer research.

The lab maintains active collaborations within East Carolina University, particularly with cancer biology and vascular research groups, creating an interdisciplinary environment for investigating RNA modification in disease processes.