Frances Widjaja-van den Ende

Frances Widjaja-van den Ende is a Research Associate in the Department of Toxicology at Wageningen University.

Education:

• PhD in Toxicology, Wageningen University, 2024

Her research centers on pyrrolizidine alkaloids (PAs) and their N-oxides, with expertise in mixture toxicity risk assessment, relative potency quantification, and new approach methodologies. She investigates interindividual kinetic differences, low-dose effects, and dose-response relationships using integrated in vitro-in silico models, bridging toxicology with food safety and regulatory science.

Recent publications (2024-2025) reveal a consistent focus on PA N-oxide toxicity mechanisms, with emphasis on refining relative potency factors through computational modeling and human-relevant endpoints. Her work directly informs chemical safety frameworks for plant-derived food and feed contaminants.

Scientific Awards:

• No scientific awards mentioned

Dr. Widjaja-van den Ende completed her PhD under Prof. Rietjens, Dr. Wesseling, and Dr. van Boekel. No student advising is documented. Her research was supported by the PhD project "Alternative testing strategies to quantify the toxicity of pyrrolizidine alkaloid N-oxides" (2019-2024).

She actively collaborates within Wageningen University's toxicology division and international networks, contributing to workshops on botanical drug safety and regulatory harmonization for natural toxins.