Flaviano Giorgini

Professor Flaviano Giorgini is a Professor of Neurogenetics at the University of Leicester, affiliated with the Genetics and Genome Biology Department. His research focuses on neurodegenerative diseases, particularly Huntington’s, Parkinson’s, and Alzheimer’s, with a strong emphasis on the kynurenine pathway and mitochondrial dysfunction. Giorgini transitioned from a 2006 Lecturer role to Reader in 2012, achieving full professorship in 2015. His work integrates model organisms, including Drosophila and yeast, to study protein aggregation, synaptic dysfunction, and therapeutic targets.

Giorgini’s research highlights interdisciplinary collaborations through networks like the European Huntington’s Disease Network (EHDN), focusing on clinical translation and biomarker development. Key areas include kynurenine pathway modulation, mitochondrial calcium uniporter (MCU) function, and Rab GTPase signaling. His lab investigates how metabolic pathways and protein interactions influence neurodegeneration, with recent advances in neuroprotective agents and diagnostic methods like AGERA for mutant aggregates.

Publications from 2022-2025 emphasize novel insights into kynurenine pathway dynamics, mitochondrial dysfunction, and neuroinflammation. Notable contributions include identifying KMO as a therapeutic target, demonstrating mitochondrial rescue mechanisms in Huntington’s models, and exploring tubulin modifications in vascular dementia. Awards and grants are not explicitly listed but reflect sustained funding for his impactful research programs.