معرفی
Dr. Fei Chen serves as Assistant Professor in Harvard University's Department of Stem Cell and Regenerative Biology and as Core Faculty at the Broad Institute of Harvard and MIT. His laboratory pioneers transformative technologies at the intersection of microscopy, genomics, and synthetic biology to bridge spatial and temporal dimensions in tissue analysis.
His educational foundation includes a Ph.D. in Biological Engineering from the Massachusetts Institute of Technology, followed by a Schmidt Fellowship at the Broad Institute.
Research focuses on decoding spatial organization and temporal dynamics of complex tissues through innovations like expansion microscopy (co-invented during doctoral work), Slide-seq, and Slide-tags. Current efforts map cell-type localization within intact tissues and track transcriptional activity during neurodevelopment and disease progression, with applications spanning developmental biology, neuroscience, and injury response mechanisms.
Recent publications demonstrate accelerating innovation in spatial genomics, evolving from foundational imaging techniques to advanced computational reconstruction methods. This trajectory reveals deepening integration of single-cell resolution with tissue architecture analysis, particularly advancing neuroscience applications through mouse brain mapping and neurodevelopmental studies.
Major recognitions include:
- Allen Distinguished Investigator Award
- Searle Scholars Award
- NYSCF Robertson Investigator Award
Dr. Chen actively mentors graduate researchers including Chenlei Hu (RECON publication in Nature Biotechnology 2025) and Dawn Chen (HACE in Science 2024), supported by award-associated research funding. Lab culture emphasizes collaboration through annual retreats and events like the 2025 Chen Lab BBQ.
The Chen Lab operates from the Broad Institute campus in Cambridge, MA, maintaining a dynamic interdisciplinary team that combines experimental biology with computational innovation to decode tissue organization principles in health and disease.
