معرفی
Full Professor of Pharmaceutical Chemistry at the University of Siena, Department of Biotechnology, Chemistry and Pharmacy. Professor Manetti specializes in medicinal chemistry with a focus on drug design, molecular modeling, and the development of therapeutics for various diseases including cancer, neurological disorders, infectious diseases, and rare genetic conditions. His research spans multiple areas of pharmaceutical sciences, from traditional drug discovery to innovative approaches like light-mediated drug activation and covalent ligand design.
Professor Manetti's research interests include Medicinal Chemistry, Pharmaceutical Chemistry, Toxicological Chemistry, Nutraceutical-Food Chemistry, Drug Design, and Molecular Modeling. His work particularly focuses on enzyme inhibition strategies, cancer therapeutics development, antiviral research, and the application of computational methods in drug discovery. He has made significant contributions to the understanding of Hedgehog signaling pathway inhibitors, P-glycoprotein inhibitors, and novel approaches to treat conditions like alkaptonuria and SARS-CoV-2 infection.
His publication record demonstrates expertise across multiple therapeutic areas, with particular emphasis on cancer research (hepatocellular carcinoma, glioblastoma, melanoma), infectious diseases (tuberculosis, SARS-CoV-2), neurological disorders (Alzheimer's disease), and rare genetic conditions (alkaptonuria). Professor Manetti employs diverse methodologies including molecular hybridization, covalent ligand design, in silico modeling, and structure-activity relationship studies to develop novel therapeutic agents.
Professor Manetti's scientific contributions include numerous publications in high-impact journals across pharmaceutical sciences, medicinal chemistry, and related fields. His work has addressed important challenges in drug development, including overcoming drug resistance mechanisms, improving drug selectivity, and developing novel therapeutic approaches for difficult-to-treat conditions.
Professor Manetti maintains active research collaborations and supervises students in the Department of Biotechnology, Chemistry and Pharmacy at the University of Siena. His laboratory focuses on the design, synthesis, and evaluation of novel compounds with potential therapeutic applications across multiple disease areas. Current research directions include the development of theranostic approaches for cancer treatment, covalent inhibitors for challenging targets, and repurposing existing drugs for new therapeutic applications.
