Fabian Benencia

Fabian Benencia is an Associate Professor in the Department of Biomedical Engineering at Ohio University's Russ College of Engineering and Technology. His research focuses on immunity responses in diseases, particularly diabetes, obesity, and cancer biology. Key areas include tumor microenvironment modulation, inflammatory processes in metabolic disorders, and the interplay between growth hormones and adipose tissue immunology.

His work spans in vivo and in vitro models, with contributions to understanding Toll-like receptor (TLR) signaling in cancer immunology, chemokine networks in tumor immune infiltration, and the role of dsRNA receptors in cancer-associated inflammation. Collaborations include studies on oncolytic viruses, immunotherapeutic strategies, and growth hormone-deficient mouse models.

Publications highlight his expertise in cancer immunology, metabolic inflammation, and stress-endocrine-immune interactions. He has contributed chapters to scholarly books on dendritic cell biology and mRNA-based vaccines. His research integrates systems biology approaches to address cancer prevention and therapy through tumor microenvironment modulation.

Notably, he investigates how substrates and soluble factors influence dendritic cell behavior, with implications for vaccine design. His lab explores antitumor vaccination strategies, cytokine networks in obesity, and the immunosuppressive role of regulatory T cells in ovarian cancer.