Eric C Chang

Eric C Chang, Ph.D. is a Professor at Baylor College of Medicine in Houston, Texas, with appointments in the Breast Center and as a Member of the Dan L Duncan Comprehensive Cancer Center. His research focuses on molecular mechanisms of cell signaling, particularly Ras protein pathways and their role in cancer development and progression.

Dr. Chang's research interests span molecular biology, cell signaling, cancer research, and proteasome function, with particular emphasis on how Ras proteins coordinate multiple signaling inputs and outputs. His work has examined compartmentalized Ras signaling in fission yeast models and translated these findings to breast cancer research, investigating how Ras signaling contributes to tumor formation and progression.

Analysis of Dr. Chang's publication history reveals a consistent research trajectory from fundamental cell signaling mechanisms in model organisms to direct applications in breast cancer biology. His most recent work focuses on neurofibromin's role as an estrogen receptor co-repressor and the therapeutic implications for CDK4/6 inhibitors in specific breast cancer subtypes. Earlier work established foundational knowledge about Ras compartmentalization and its effects on cellular transformation.

• Ph.D. from State University Of New York At Buffalo (1989)
• Advanced Training from Cold Spring Harbor Laboratory (1992)
• B.S. from National Taiwan University (1981)

Dr. Chang maintains an active research laboratory investigating the molecular mechanisms of cancer development, with particular focus on signaling pathways that could serve as therapeutic targets. His work bridges basic molecular biology and translational cancer research, contributing significantly to our understanding of how signaling specificity is achieved in complex cellular environments.