معرفی
Emmanuelle Schindler, MD, PhD, is an Assistant Professor of Neurology at Yale School of Medicine and serves as Medical Director of the Headache Center of Excellence at the VA Connecticut Healthcare System. Her clinical and research work focuses on headache disorders, with particular expertise in cluster headache, a severely painful condition sometimes called "suicide headache." Dr. Schindler is pioneering research on psilocybin and other psychedelic compounds for the treatment of cluster, migraine, and post-traumatic headaches.
Education
- Advanced Research Fellow, VA Connecticut Healthcare System (2018)
- Residency, Yale School of Medicine (2016)
- MD, Drexel University College of Medicine (2012)
- PhD in Neuroscience, Drexel University College of Medicine (2010)
- BS in Biological Psychiatry, College of William & Mary (2003)
Dr. Schindler's research centers on innovative approaches to headache management, particularly the therapeutic potential of psychedelic compounds. She has developed and executed the first controlled trials investigating psilocybin's effects on cluster headache, migraine, and post-traumatic headache. Her work explores how limited dosing of psychedelics can produce sustained reductions in headache burden, examining neurobiological systems involved in both headache pathology and psychedelic mechanisms. Beyond psychedelic research, she focuses on improving recognition and management of cluster headache, an area where basic treatments like inhaled oxygen remain inaccessible to many patients despite the condition's severity.
Dr. Schindler's publication record demonstrates a strong trajectory in headache research with increasing focus on psychedelic medicine. Her recent work spans clinical trials, mechanistic studies, ethical considerations, and epidemiological analyses related to headache disorders. She has made significant contributions to understanding gender differences in cluster headache presentation, the role of CGRP signaling in migraine pathophysiology, and the adaptation of psychedelic compounds for headache treatment. Her research often bridges neurology, pharmacology, and mental health, reflecting the complex nature of headache disorders.
Scientific Awards
- Kindness Award (2019) from VA Connecticut Healthcare System
- Gilbert Glaser Award (2015) from Yale School of Medicine
- American Academy of Neurology Award (2012)
Dr. Schindler actively contributes to professional organizations including the American Academy of Neurology (since 2003), American Headache Society (since 2014), International Headache Society (since 2017), and International Society for Research on Psychedelics (since 2019). Her collaborative research network includes prominent Yale colleagues such as Jason Sico, Deepak D'Souza, and Christopher Gottschalk. While specific grant information isn't detailed in the provided text, her active clinical trial work suggests significant research funding support for her innovative approaches to headache treatment.
As Medical Director of the Headache Center of Excellence at the VA Connecticut Healthcare System, Dr. Schindler leads a multidisciplinary team focused on optimizing headache management for veterans. Her work bridges academic research at Yale with direct clinical care in the Veterans Affairs system, creating a unique environment for translating scientific discoveries into patient benefits. She emphasizes the importance of education at multiple levels, from federal regulatory bodies to patient communities, to improve recognition and treatment of cluster headache.