معرفی
Emiliana Borrelli, PhD holds a joint appointment as Professor in the Department of Microbiology & Molecular Genetics and Pharmaceutical Sciences at the University of California, Irvine School of Medicine. Her research focuses on dopamine receptor signaling mechanisms in neural circuits, particularly in striatal interneurons and their roles in movement disorders, addiction, and psychiatric conditions. Using genetically modified mice, her lab investigates how dopamine receptor subtypes (D1/D5 and D2L/D2S) regulate synaptic transmission and neuronal plasticity in the basal ganglia.
Key research areas include dopamine receptor subtype-specific actions on cholinergic and parvalbumin-positive interneurons, circadian rhythm regulation via dopaminergic pathways, and molecular mechanisms underlying antipsychotic drug responses. Her work has identified critical roles for D2 receptors in modulating GABAergic transmission and striatal circuit function.
Recent studies explore dopamine receptor contributions to cocaine addiction susceptibility, L-DOPA-induced dyskinesia in Parkinson's disease, and circadian metabolomic profiles. She has published extensively in high-impact journals such as Nature Neuroscience, Neuron, and Proceedings of the National Academy of Sciences.
