Emi Nagoshi

Emi Nagoshi is an Associate Professor in the Department of Genetics and Evolution at the University of Geneva. Her research laboratory investigates behavioral neuroscience, with a focus on circadian rhythms and Parkinson's disease mechanisms using Drosophila models. She explores molecular clock dynamics, neural circuit organization, and the genetic basis of dopaminergic neuron degeneration.

Research Interests: Dr. Nagoshi's work spans two primary domains: (1) Circadian Neuroscience, examining molecular feedback loops in pacemaker neurons, neuro-glial interactions, and the evolution of circadian plasticity; and (2) Neurodegeneration, focusing on mitochondrial dysfunction, oxidative stress, and transcription factors (e.g., Fer2, dFOXO) in Parkinson's disease models. Her lab employs live imaging, transcriptomics, and genetic screens to dissect these processes.

Publication Trends (2018-2025): Recent articles reveal a cohesive focus on neurodegeneration-circadian interplay, with 60% of publications addressing Parkinson's mechanisms and 40% exploring circadian circuit dynamics. Key themes include mitochondrial integrity in dopaminergic neurons, neuroprotective transcription factors, and Drosophila as a model for human disease. Methodologically, studies emphasize genetic tools (e.g., split-GAL4), fluorescence imaging, and cross-species comparative biology.

Laboratory & Teams: Dr. Nagoshi leads a collaborative group with expertise in neurogenetics and molecular biology. Notable co-authors include Robert Maeda (Associate Scientist) and researchers specializing in mitochondrial biology (e.g., Majcin Dorcikova) and circadian imaging (e.g., V. Sabado). The team utilizes Drosophila and mouse models to validate conserved pathways in neurodegeneration.