Sabine Krabbe

Dr. Sabine Krabbe is a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Bonn. Her research focuses on neural circuits mediating adaptive learning and decision-making, particularly in relation to emotional/metabolic states and neurodegenerative diseases like Parkinson's. She employs advanced techniques such as single-cell activity measurements, optogenetics, and pharmacogenetics in mouse models.

Her work explores how internal states (e.g., fear, hunger) modulate brain networks involving the ventral midbrain, striatum, and amygdala. She investigates pathological neuronal activity in early Parkinson's disease, linking it to cognitive and psychiatric symptoms preceding motor decline. Her lab also studies synaptic connectivity, neuronal diversity, and plasticity mechanisms using anatomical and molecular methods.

Research trends include fear learning circuits, dopaminergic/GABAergic neuron interactions, neuroimaging in neurodegeneration, and cross-species behavioral comparisons. Key methodologies involve miniature microscopes, 3-photon imaging, and BRISC synaptic mapping. No scientific awards are mentioned in the provided text.

Her lab actively participates in collaborative neuroscience initiatives and shares findings via open-access platforms. Current projects address how brain networks integrate internal states, pathological mechanisms in Parkinson's, and the role of neuromodulation in adaptive behavior.