معرفی
Professor Elisa Laurenti holds a faculty position at the Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge. Her research focuses on understanding human hematopoietic stem cell (HSC) biology across health, aging, and disease contexts.
- Cambridge Stem Cell Institute
- Department of Haematology, University of Cambridge
Research Overview: Elisa's lab employs single-cell biology techniques to investigate HSC functional heterogeneity, stress responses, and age-related changes that impact regenerative medicine and blood cancer therapies. Key areas include:
- Transcriptional landscapes of HSCs across hematopoietic sites
- Stem cell adaptation to ex vivo culture
- Molecular mechanisms of erythroid priming in β-thalassemia
- Clonal dynamics during human aging
- Stress-induced signaling pathways (TGFβ, TNFα-NFκB)
- Stem cell-niche interactions in health and disease
Scientific Awards:
- International Society for Experimental Hematology Janet Rowley Award (2021)
Key Contributions: Elisa's work has advanced understanding of:
- Human HSC dormancy regulation
- Extramedullary hematopoiesis mechanisms
- Chemotherapy-induced genomic toxicity
- Functional assays for HSC lineage commitment
- Computational models of clonal dynamics
Laboratory: Located at the Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, her group includes postdocs, PhD students, and research associates investigating HSC behavior through experimental and computational approaches. Funding sources include Wellcome Trust, Royal Society, Aging Biology Foundation, and Leukemia & Lymphoma Society.
