معرفی
Eli E. Bar serves as Associate Professor in the Department of Neurosurgery at the University of Maryland School of Medicine, with secondary appointments in Pathology and membership in both the Molecular Medicine Program and Marlene and Stewart Greenebaum Comprehensive Cancer Center.
His educational background includes a PhD in Molecular Biology from the University of Illinois at Chicago followed by a Postdoctoral Fellowship in Cancer Cell Biology at Johns Hopkins University.
Dr. Bar's research program centers on glioblastoma microenvironmental dynamics, specifically investigating how hypoxia and nutrient deprivation activate HIF pathways and MCT4 transporters to promote glioma stem-like cell maintenance. His laboratory examines crosstalk between microenvironmental factors and stemness pathways (Notch, Hedgehog), RNA-binding protein-mediated therapy resistance, and BRAF-driven mechanisms in pediatric low-grade gliomas. This work integrates molecular biology, metabolic profiling, and preclinical drug testing.
Analysis of his 2014-2019 publications reveals consistent focus on targeting metabolic vulnerabilities (MCT4, carbonic anhydrase 9) and signaling nodes in brain tumors, with significant contributions to understanding hypoxia-induced stemness and invasion mechanisms across multiple cancer types.
Dr. Bar actively mentors laboratory personnel and collaborates within the Greenebaum Cancer Center's multidisciplinary framework, with research supported through institutional funding and collaborative grants focused on therapeutic development.
His laboratory operates within the university's neuroscience research infrastructure, utilizing advanced models including glioma neurospheres and in vivo systems to investigate tumor-microenvironment interactions and therapeutic responses.
