Edward V. Quadros

Edward V. Quadros, PhD, serves as a Research Professor in the Department of Cell Biology at SUNY Downstate Medical Center, contactable via Edward.Quadros@downstate.edu or (718) 270-4203. His work bridges nutritional biochemistry, neuroscience, and oncology through molecular investigations of vitamin pathways.

His research centers on vitamin B12 and folate metabolism, examining biochemical mechanisms of absorption, transport, and genetic abnormalities in dependent pathways. He investigates cellular consequences of deficiencies in cardiovascular disease, Alzheimer's dementia, and neuropathology, with emphasis on DNA methylation in the brain. A major focus explores folate receptor autoimmunity's role in neural tube defects, cerebral folate deficiency, and autism spectrum disorders, demonstrating folinic acid's therapeutic potential. Concurrently, he develops cancer therapeutics using vitamin analogs for targeted drug delivery and receptor-mediated depletion strategies.

Current laboratory projects include:

• Folate receptor autoimmune disorder treatment using folinic acid for autism spectrum disorders
• Rat models studying folate deficiency and antibody exposure effects on neurodevelopment
• CD320 knockout models for B12 deficiency in the central nervous system
• Targeting transcobalamin receptor (CD320) and folate receptor (FRalpha) in cancer therapy

No scientific awards were documented in the source material.

Dr. Quadros leads an active laboratory investigating vitamin-mediated pathways without specified advisees or grant details in the provided text, with future work focused on diagnostic markers for autism risk and mechanistic studies of B12 in embryogenesis.