Dorthe Schaue

Dorthe Schaue is an Adjunct Professor in the Radiation Oncology Department at the University of California Los Angeles (UCLA) School of Medicine. Her expertise lies at the intersection of radiation biology, tumor immunity, and cytokine signaling.

• Principal Investigator, NIH U01AI148322 (2020-2025): Acute radiation injury and microRNA biomarkers
• Co-Principal Investigator, NIH R21CA228542 (2019-2021): Radiation-induced tumor immune responses
• Principal Investigator, NIH R01CA226875 (2019-2024): Myeloid cell reprogramming post-radiation
• Principal Investigator, NIH R01CA191234 (2015-2020): Radiotherapy-induced tumor immunity

Her research spans multiple cancer types including prostate cancer, glioblastoma, head/neck squamous cell carcinoma, and soft-tissue sarcomas. Key themes include:

• Radiation-induced immune modulation
• Tumor microenvironment dynamics
• DNA repair mechanisms in radioresistance
• Development of polymer-based drug delivery systems
• Age-related radiation responses

Recent publications demonstrate her focus on combining radiation with immunotherapy, particularly through:

• Radioimmunotherapy using [225Ac]Ac-FAPI-46
• Metabolic reprogramming in glioblastoma
• Immune biomarker identification
• Modular polymer platforms for cytokine delivery

She has collaborated with leading researchers in radiation oncology, cancer biology, and immunotherapy, including:

• Dr. William H. McBride
• Dr. Nicholas G. Nickols
• Dr. Erina Vlashi
• Dr. Christine Mona
• Dr. Steven M. Dubinett