معرفی
Dima Kozakov is a Research Professor in the Department of Biomedical Engineering at Boston University. He holds a PhD in Biomedical Engineering from Boston University and an M.Sci. in Applied Mathematics and Physics from the Moscow Institute of Physics and Technology. His research focuses on macromolecular recognition, signaling protein-protein interaction networks, genome drugability, and protein design. He is affiliated with the Research Faculty at BU and has contributed to advancements in computational methods for structural biology and drug discovery.
His work integrates advanced Fourier and optimization techniques to explore macromolecular interaction landscapes, including structure determination of macromolecular complexes from low-resolution data and validation of protein interaction networks. He develops methods for fragment-based drug design, identifying cryptic binding sites amenable to small molecule inhibition in cancer pathways, and designs peptidic chaperones for crystallization. His contributions include the ClusPro docking server and FTMap pharmacophore identification tools.
Recent publications highlight his exploration of ligand interaction landscapes in E. coli, targeted protein degradation mechanisms, and AlphaFold-based structural predictions. He investigates multiomic profiles of immune cells and metabolic reprogramming in disease contexts. His research emphasizes druggable site identification, computational modeling of protein interactions, and advancing machine learning applications in structural biology.
Key innovations include MHC-Fine for precise MHC-peptide complex prediction and E-FTMap for fragment-based drug discovery. His work bridges computational methods with experimental validation, addressing challenges in protein structure prediction and drug target identification. Kozakov collaborates on projects like the CASP15 CAPRI experiment, assessing computational methods for protein complex modeling.
