معرفی
PD Dr. Dietmar Spengler serves as Project Group Leader within the Department of Genes and Environment at the Max Planck Institute of Psychiatry in Munich, Germany, focusing on the epigenomic impact of early-life adversity on mental health disorders.
His core research areas include:
- Epigenetic mechanisms (DNA methylation, histone modifications)
- Childhood trauma and maternal neglect effects
- Stress-induced neural circuit reorganization
- Neuroendocrine regulation of depression
- Molecular pathways linking environment to gene expression
- Biomarker discovery for psychiatric vulnerability
Leading the Epigenomics of Early-Life Stress group, Dr. Spengler employs dual-scale methodologies: top-down analysis of neural circuitry connected to stress phenotypes and bottom-up investigation of genetic variants affecting stress processing. His team integrates molecular biology, biochemistry, and clinical collaborations to translate findings from animal models to human depression pathophysiology, targeting novel intervention strategies through epigenomic risk factor identification.
