Dennis G Moledina

Dennis G Moledina is an Associate Professor of Medicine (Nephrology) at Yale School of Medicine with multiple leadership roles including Director of the Research Fellowship in Nephrology, Vice Chief for Research (Clinical and Translational) in Nephrology, and Director of the Kidney BioBank. His academic appointments span the Yale Cancer Center, Clinical and Translational Research Accelerator (CTRA), and Human and Translational Immunology Program.

Dr. Moledina's research program focuses on acute kidney injury (AKI), particularly acute interstitial nephritis. He has developed expertise in biomarker discovery and validation, diagnostic model development using electronic health records, and understanding kidney complications of cancer immunotherapies. As Director of the Yale Kidney BioBank, he oversees a comprehensive biorepository with samples from over 1,400 participants with kidney biopsy-confirmed diagnoses collected since 2015.

Analysis of Dr. Moledina's publication record from 2019-2025 reveals a consistent focus on urinary biomarkers for diagnosing and prognosing acute interstitial nephritis. His work integrates clinical informatics with traditional nephrology to develop practical diagnostic tools that can be implemented in electronic health records. Several recent studies examine the relationship between immune checkpoint inhibitors and kidney injury, reflecting his connection to the Yale Cancer Center and addressing an important clinical challenge in modern oncology.

• Fellow, National Kidney Foundation (2025)
• Top-rated abstract, National Kidney Foundation (2024)
• Fellow, American Society of Nephrology (2021)
• K23 Mentored Patient-Oriented Career Development Award, NIH/NIDDK (2018)
• KPMP Opportunity Pool Travel Grant, Kidney Precision Medicine Program (2018)

Dr. Moledina maintains active NIH funding for developing diagnostic testing for acute kidney injury subtypes and serves as coinvestigator in major multicenter consortia including the Kidney Precision Medicine Program (KPMP) and Care of outpatients with acute kidney injury (COPE-AKI). His leadership in the Nephrology Research Fellowship Program trains the next generation of nephrology researchers, emphasizing translational approaches to kidney disease.

The Yale Kidney BioBank under Dr. Moledina's direction represents a critical resource for kidney research, containing kidney tissue, DNA, plasma, and urine samples that have enabled significant advances in understanding acute interstitial nephritis. His collaborative network includes frequent co-authors such as F. Perry Wilson, Sherry Mansour, and Jeffrey Testani, reflecting strong interdisciplinary connections across nephrology, oncology, and clinical informatics.