معرفی
Demetri D. Spyropoulos is a Professor in the Department of Pathology and Laboratory Medicine at the Medical University of South Carolina (MUSC), College of Medicine. His research focuses on environmental obesogens, tissue preservation technologies, and transgenic animal models. He leads a laboratory investigating gene-environment interactions, particularly how exposures to endocrine disruptors influence developmental and disease pathways. His work bridges basic research with clinical applications, including patient-derived tissue models for precision medicine and iPSC-based studies on environmental impacts.
Key research areas include studying master regulator genes (e.g., HOX, PPAR/RXR, Ets family) and their epigenetic regulation by environmental agents. He pioneered methods for cryopreserving human tissues to maintain viability and 3D architecture, enabling advanced in vitro and xenograft studies. Notably, his group identified the obesogenic effects of Corexit components, a critical finding for public health and environmental policy.
Publications highlight interdisciplinary approaches, integrating toxicology, genetics, and clinical translation. His contributions to biospecimen standards (e.g., PREanalytical Code) ensure reliable biorepository practices. Collaborative projects span medical, environmental, and veterinary fields, emphasizing translational impact.
