Dejan Zecevic

Dejan Zecevic is a Senior Research Scientist at the Department of Cellular and Molecular Physiology, Yale University School of Medicine. He holds a PhD in Biophysics from the University of Belgrade (1981) and trained under Dr. Lawrence Cohen, a pioneer of voltage-sensitive dye recording. His research focuses on intracellular voltage-sensitive dye imaging, a cutting-edge technology for studying electrical signaling in axons, dendrites, and dendritic spines. Key research interests include action potentials, synaptic integration, and membrane potential dynamics in neuronal structures.

Education:

• PhD in Biophysics, University of Belgrade, Serbia (1981)

Research Interests:

Zecevic’s work centers on understanding electrophysiological properties of dendritic spines and axons using advanced imaging techniques. He developed voltage-sensitive dye methods to visualize submillisecond membrane potential changes, enabling studies of synaptic signal integration and action potential propagation. His contributions include insights into spine head electrical coupling, axonal conduction mechanisms, and stochastic aspects of dendritic signaling.

Key Research Trends:

Recent publications highlight his focus on holographic illumination for spine imaging, stochastic backpropagation in dendrites, and leak-resistant axonal conduction. Techniques like computer-generated holography and combined optical methods (voltage + calcium imaging) are central to his work, advancing neurophotonics and systems neuroscience.

Labs/Teams:

Zecevic collaborates with the Yale Neuroscience community, particularly within the Cellular & Molecular Physiology department. His lab integrates biophysics, optics, and electrophysiology to explore fundamental neuronal mechanisms.