معرفی
Karima Ait Ouares is a Research Fellow in Neuroscience at Yale School of Medicine, Yale University. Her research focuses on understanding calcium signaling dynamics in cerebellar Purkinje neurons, particularly investigating the roles of mGluR1 receptors, synaptic inputs, and ion channel regulation. She employs advanced techniques including confocal imaging, electrophysiology, and optogenetic methods to study neuronal excitability and synaptic plasticity.
Her work also extends to neuropharmacology, involving the characterization of synthetic scorpion toxins like AmmTx3 targeting cardiac potassium channels (Kv4.2) and their potential in drug development. She has developed novel imaging systems for submicron resolution in brain slices and contributed to methodological advancements in calcium current analysis.
Key areas of research include: synaptic integration mechanisms in Purkinje cells, voltage-dependent ion channel interactions, and the application of opto-non-genetic tools for neuronal inhibition. Her interdisciplinary approach bridges neurophysiology, biophysics, and pharmacology.
